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Updated: May 27, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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MOPED: Model Organism Protein Expression Database.

Eugene Kolker1, Roger Higdon, Winston Haynes

  • 1Bioinformatics and High-throughput Analysis Laboratory, High-throughput Analysis Core, Center for Developmental Therapeutics, Seattle Children's Research Institute, Predicitive Analytics, Seattle Children's Hospital, Seattle, WA 98105, USA. eugene.kolker@seattlechildrens.org

Nucleic Acids Research
|December 6, 2011
PubMed
Summary
This summary is machine-generated.

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The Model Organism Protein Expression Database (MOPED) simplifies sharing and comparing proteomics data. This resource provides access to protein expression information from human and model organism studies, aiding biological process research.

Area of Science:

  • Proteomics
  • Bioinformatics
  • Systems Biology

Background:

  • Mass spectrometry proteomics studies generate large, complex datasets.
  • Data sharing, integration, and comparison are hindered by data complexity.
  • A centralized resource is needed for efficient proteomics data management.

Purpose of the Study:

  • To introduce the Model Organism Protein Expression Database (MOPED) as a solution for managing proteomics data.
  • To facilitate the sharing, integration, and comparison of proteomics studies.
  • To enable researchers to visualize and compare their own data with existing studies.

Main Methods:

  • Developed MOPED, a web-based proteomics resource.
  • Integrated protein expression data from human and model organism studies.

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  • Implemented querying and browsing functionalities based on various criteria (organism, tissue, condition, etc.).

    • Main Results:

    • MOPED provides rapid browsing of protein expression information.
    • The database includes protein-level expression data, meta-analysis, and standardized quantitative data.
    • Current version contains over 43,000 proteins and 11 million spectra.
    • Links to external databases like GeneCards, UniProt, KEGG, and Reactome are provided.

    Conclusions:

    • MOPED simplifies the comparison and sharing of proteomics data for the research community.
    • The resource empowers researchers to analyze and contextualize their findings.
    • MOPED enhances the utility of publicly available proteomics studies.