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Updated: May 27, 2026

Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine

Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine

Published on: November 4, 2018

Cell therapies for liver diseases.

Yue Yu¹, James E Fisher, Joseph B Lillegard

¹Division of Experimental Surgery, Department of Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

|December 6, 2011

Summary

Cell therapies, including bioartificial liver support and hepatocyte transplantation, offer promising treatments for various liver diseases. These innovative approaches show potential for treating acute liver failure, inherited metabolic disorders, and even liver cancer.

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Area of Science:

Regenerative Medicine
Hepatology
Cell-Based Therapies

Background:

Cell therapies are emerging as viable treatments for liver diseases.
Bioartificial liver support and hepatocyte transplantation are key examples.
Existing treatments have shown success in acute liver failure and inherited metabolic diseases.

Purpose of the Study:

To summarize current concepts in cell therapy for liver diseases.
To highlight the potential applications of cell therapies.
To discuss the role of cell therapy in improving liver transplantation outcomes.

Main Methods:

Review of current literature on cell therapy for liver diseases.
Analysis of successful clinical applications of cell therapies.
Exploration of future potential for cell-based treatments.

Main Results:

Cell therapies have demonstrated success in treating acute liver failure, acute-on-chronic liver failure, and inherited metabolic liver diseases.
These therapies are being explored for noninherited liver diseases and liver cancer.
Cell therapies hold promise for enhancing the success rates of liver transplantation.

Conclusions:

Cell therapy represents a significant advancement in managing diverse liver conditions.
The scope of cell therapy applications in hepatology is expanding.
Further research and application of cell therapies could revolutionize liver disease management and transplantation.