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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

HGPD: Human Gene and Protein Database, 2012 update.

Yukio Maruyama¹, Yoshifumi Kawamura, Tetsuo Nishikawa

¹National Institute of Advanced Industrial Science and Technology, Japan Biological Informatics Consortium, Aomi, Koto-ku, Tokyo 135-0064, Japan.

Nucleic Acids Research

|December 6, 2011

Summary

The Human Gene and Protein Database now offers over 43,000 human Gateway entry clones, including new protein expression data and cellular localization information for enhanced gene function research.

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Area of Science:

Biotechnology
Genomics
Proteomics

Background:

The Human Gene and Protein Database (HGPD) was established in 2008 to store human Gateway entry clone information.
It previously held 33,275 clones derived from full-length cDNA open reading frames (ORFs).
Research increasingly focuses on protein information for drug development and diagnostics.

Purpose of the Study:

To expand the HGPD collection with new human Gateway entry clones.
To incorporate protein expression, synthesis, and cellular localization data.
To improve data retrieval and searchability within the database.

Main Methods:

Construction of 9,974 additional human Gateway entry clones, totaling 43,249.
Classification of clones into 10 functional groups.
Inclusion of in vivo cellular localization data for 32,651 clones.
Display of ORF regions in search results for easier identification.

Main Results:

The database now comprises 43,249 human Gateway entry clones, named the Human Proteome Expression Resource (HuPEX).
Protein functional classification and in vivo cellular localization data are now available for a significant portion of the clones.
Enhanced search functionality includes ORF region visualization.

Conclusions:

The expanded HGPD, including HuPEX, provides a comprehensive resource for human protein research.
The integrated data facilitates studies on gene function, protein expression, and cellular localization.
This resource supports advancements in medicine, diagnostics, and therapeutic development.