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Related Experiment Video

Updated: May 27, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Glomerular hyperfiltration in prediabetes and prehypertension.

Rieko Okada¹, Yoshinari Yasuda, Kazuyo Tsushita

¹Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan. rieokada@med.nagoya-u.ac.jp

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association

|December 6, 2011

Summary

Glomerular hyperfiltration is linked to worsening prediabetes and prehypertension. Monitoring kidney function is crucial for individuals with these conditions to prevent kidney damage.

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Assessment of Kidney Function in Mouse Models of Glomerular Disease

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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

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Published on: May 2, 2025

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

Area of Science:

Nephrology
Endocrinology
Cardiology

Background:

Investigating the relationship between abnormal kidney filtration (hyperfiltration and hypofiltration) and the progression of prediabetes and prehypertension.
Understanding the clinical significance of glomerular filtration rate (eGFR) abnormalities in metabolic and hypertensive disorders.

Purpose of the Study:

To determine the association between hyperfiltration and hypofiltration with different stages of prediabetes and prehypertension.
To provide evidence for early intervention strategies in individuals at risk of kidney damage.

Main Methods:

Analysis of health checkup data from 99,140 individuals aged 20-89 years in Japan.
Comparison of hyperfiltration (eGFR > 95th percentile) and hypofiltration (eGFR < 5th percentile) prevalence across prediabetes and prehypertension stages.
Statistical analysis using odds ratios (ORs) to quantify associations.

Main Results:

A significant increase in hyperfiltration prevalence was observed with advancing stages of prediabetes (ORs: 1.29-2.47) and prehypertension (ORs: 1.10-1.52).
Hypofiltration showed no significant association with either prediabetes or prehypertension.
The odds of hyperfiltration increased substantially in individuals with diabetes and Stage 2 prehypertension.

Conclusions:

Glomerular hyperfiltration prevalence escalates with the progression of prediabetes and prehypertension.
Regular monitoring of kidney function is recommended for individuals diagnosed with prediabetes or prehypertension.
Early management of hyperglycemia and elevated blood pressure in hyperfiltering individuals may be essential for preventing renal damage.