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Telmisartan and cardioprotection

Philippe R Akhrass1, Samy I McFarlane

  • 1State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA.

Vascular Health and Risk Management
|December 6, 2011
PubMed

Insights

Telmisartan, an angiotensin receptor blocker (ARB), shows promise in reducing cardiovascular risk. Clinical trials like ONTARGET and TRANSCEND evaluated its cardioprotective effects in high-risk patients.

Area of Science:

  • Cardiology
  • Pharmacology
  • Internal Medicine

Background:

  • The renin-angiotensin-aldosterone system (RAAS) is implicated in atherosclerosis and cardiovascular disease (CVD) pathogenesis.
  • RAAS blockade, particularly with angiotensin converting enzyme (ACE) inhibitors, is a recognized cardioprotective strategy.
  • Angiotensin receptor blockers (ARBs) effectively lower blood pressure, but their role in CVD risk reduction is under investigation.

Purpose of the Study:

  • To highlight the cardioprotective role of telmisartan, an ARB.
  • To review the findings of the ONTARGET and TRANSCEND randomized controlled trials regarding telmisartan's efficacy.

Main Methods:

  • Review of two major randomized controlled trials: ONTARGET and TRANSCEND.
  • Evaluation of telmisartan's effects on cardiovascular endpoints in high-risk patient populations.
  • Comparison of telmisartan alone versus in combination with ramipril (ONTARGET) and telmisartan in ACE inhibitor-intolerant patients (TRANSCEND).

Main Results:

  • Telmisartan demonstrated a promising role in reducing cardiovascular risk in high-risk individuals.
  • ONTARGET trial results provided insights into telmisartan's efficacy and safety profile.
  • TRANSCEND study assessed telmisartan's benefits in patients intolerant to ACE inhibitors.

Conclusions:

  • Telmisartan emerges as a significant therapeutic option for cardiovascular risk reduction.
  • The findings support the use of telmisartan in managing high-risk cardiovascular patients.
  • Further research may elucidate the full potential of telmisartan in cardioprotection.

Keywords:
ONTARGETTRANSCENDcardioprotectiontelmisartan

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