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Related Concept Videos

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Vision01:24

Vision

Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

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Diabetic Retinopathy01:27

Diabetic Retinopathy

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Huntington Disease l: Introduction

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Updated: May 26, 2026

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
08:17

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

True precocious puberty with vision loss.

Vimal Upreti1, Anil Bhansali, Kanchan K Mukherjee

  • 1Postgraduate Institute of Medical Education & Research, Chandigarh, 160012, India.

BMJ Case Reports
|December 6, 2011
PubMed
Summary
This summary is machine-generated.

A pediatric pilocytic astrocytoma in the sellar region caused vision loss and precocious puberty in a young boy. Surgical removal was performed, but the patient later died from sepsis.

Related Experiment Videos

Last Updated: May 26, 2026

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
08:17

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

Area of Science:

  • Pediatric neuro-oncology
  • Endocrinology

Background:

  • Pilocytic astrocytomas are common pediatric brain tumors.
  • Sellar and suprasellar tumors can present with diverse neurological and endocrine symptoms.

Purpose of the Study:

  • To report a rare case of pilocytic astrocytoma presenting with both vision loss and precocious puberty.
  • To highlight the diagnostic and management challenges of sellar region tumors in children.

Main Methods:

  • Case report of a 7-year-old boy.
  • Clinical presentation, neuroimaging, surgical resection, and histopathological analysis.
  • Postoperative course and outcome documentation.

Main Results:

  • The patient exhibited progressive vision loss and precocious puberty.
  • A solid cystic tumor in the sellar/suprasellar region was identified.
  • Histopathology confirmed pilocytic astrocytoma.
  • The patient developed postoperative sepsis and succumbed.

Conclusions:

  • Pilocytic astrocytoma can manifest with unusual combinations of symptoms, including visual and endocrine disturbances.
  • Early diagnosis and surgical intervention are crucial for sellar region tumors.
  • Postoperative complications, such as sepsis, remain a significant concern in pediatric neurosurgery.