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Personality traits and the R668Q polymorphism located in the MMP-9 gene

Petra Suchankova1, Robert Pettersson, Kajsa Nordenström

  • 1Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, P.O. Box 431, SE-405 30 Gothenburg, Sweden. petra.suchankova@pharm.gu.se

Behavioural Brain Research
|December 7, 2011
PubMed

Insights

Matrix metalloproteinase-9 (MMP-9) gene variations influence personality traits. A specific MMP-9 polymorphism (R668Q) showed distinct associations with aggression and irritability in women and men, respectively.

Area of Science:

  • Neuroscience
  • Genetics
  • Psychology

Background:

  • Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins and contribute to neuroinflammation.
  • MMP-9 (gelatinase B) is implicated in synaptic and behavioral plasticity.
  • Understanding MMP-9's role in mental functions requires genetic investigation.

Purpose of the Study:

  • To explore the influence of a specific MMP-9 gene polymorphism on personality traits.
  • To investigate sex-specific associations between MMP-9 genotype and personality.

Main Methods:

  • Analysis of a non-synonymous single nucleotide polymorphism (R668Q, rs17577) in the MMP-9 gene.
  • Assessment of personality traits using the Karolinska Scales of Personality in male and female cohorts.
  • Correlation of MMP-9 genotype with specific personality measures.

Main Results:

  • The R668Q polymorphism in MMP-9 was associated with personality differences between sexes.
  • In females, the arginine (R) to glutamine (Q) substitution correlated with higher inhibition of aggression scores.
  • In males, the same substitution was linked to increased verbal aggression and irritability.

Conclusions:

  • The study provides evidence for MMP-9's influence on mental functions, specifically personality traits.
  • Genetic variations in MMP-9 may contribute to sex-differentiated behavioral patterns.
  • Further research into MMP-9's role in neurobiology and behavior is warranted.

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