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Updated: May 26, 2026

Direct Synthesis of EM-Visible Gold Nanoparticles in Cells for Protein Localization Analysis with Well-Preserved Ultrastructure
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Structural study on gold nanoparticle functionalized with DNA and its non-cross-linking aggregation.

Masahiro Fujita1, Yoshizumi Katafuchi, Kazuki Ito

  • 1Bioengineering Laboratory, RIKEN, Hirosawa 2-1, Wako, Saitama 351-0198, Japan. mfujita@riken.jp

Journal of Colloid and Interface Science
|December 7, 2011
PubMed
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DNA-functionalized gold nanoparticles aggregate without cross-linking. Van der Waals forces and steric repulsion from DNA influence this aggregation, impacting colloidal stability and particle spacing.

Area of Science:

  • Nanotechnology
  • Biophysics
  • Materials Science

Background:

  • Colloidal nanoparticles functionalized with DNA are crucial in nanotechnology.
  • Understanding DNA-mediated nanoparticle aggregation is key for designing advanced materials.

Purpose of the Study:

  • To investigate the structural mechanisms of non-cross-linking aggregation in DNA-functionalized gold nanoparticles.
  • To elucidate the roles of DNA length, core size, and interparticle forces in aggregation behavior.

Main Methods:

  • Synchrotron radiation small-angle X-ray scattering (SR-SAXS) was the primary technique.
  • Systematic variation of DNA lengths and gold nanoparticle core sizes was employed.

Main Results:

  • Aggregation increased surface distance between nanoparticles with DNA length, showing DNA interdigitation.

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  • Aggregation occurred between identical cores, independent of tethered DNA length.
  • Increased DNA length relative to core size enhanced colloidal stability, even with full DNA duplex matching.

    • Conclusions:

    • Van der Waals interactions between nanoparticle cores, not DNA end-to-end stacking, dominate attraction.
    • Steric repulsion from DNA's entropic fluctuations is critical in non-cross-linking aggregation.
    • Colloidal stability is tunable by adjusting the ratio of DNA length to nanoparticle core size.