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Impact of vascular calcification on corrected QT interval at the time of renal transplantation

Kathleen J Claes1, Sam Heye, Dieter Nuyens

  • 1Department of Nephrology and Renal Transplantation, University Hospital Gasthuisberg, Leuven, Belgium. kathleen.claes@uzleuven.be

American Journal of Nephrology
|December 7, 2011
PubMed

Insights

Sudden cardiac death is common in dialysis patients. This study found that aortic calcification is linked to a prolonged QT interval in patients with end-stage renal disease.

Area of Science:

  • Nephrology
  • Cardiology
  • Clinical Medicine

Background:

  • Sudden death is the primary cause of cardiac mortality in dialysis patients.
  • Prolonged QT interval and arterial calcification are linked to cardiovascular risks in chronic kidney disease (CKD) patients.

Purpose of the Study:

  • To investigate the association between vascular calcification and corrected QT interval duration in end-stage renal disease (ESRD) patients.

Main Methods:

  • A single-center, cross-sectional study included 193 patients undergoing renal transplantation evaluation.
  • Patients on QT-prolonging medications or with conduction abnormalities were excluded.
  • Aortic calcifications were quantified using lumbar X-rays.

Main Results:

  • A prolonged QT interval was present in 26% of the study population.
  • Multivariate analysis revealed a significant, independent association between corrected QT duration and aortic calcification extent (p = 0.0004).
  • This association remained significant after adjusting for age, gender, cardiovascular history, electrolytes, and mineral metabolism parameters.

Conclusions:

  • A prolonged QT interval is common in patients with CKD stage 5D.
  • Aortic calcification is independently associated with prolonged QT duration in this patient group, irrespective of traditional risk factors.
Abstract

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