Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Urinary Tract Calculi I: Introduction01:28

Urinary Tract Calculi I: Introduction

Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Damned if you do, damned if you don't: contextual decision-making around SOGI data collection in the Deep South.

Frontiers in public health·2026
Same author

Osteopathic Manipulative Treatment for Complex Regional Pain Syndrome: A Scoping Review of Current Evidence.

Cureus·2026
Same author

Multilayer control of KaiR1D-autoreceptor function by the auxiliary protein Neto.

bioRxiv : the preprint server for biology·2025
Same author

A genome assembly of the California poppy, Eschscholzia californica.

The Journal of heredity·2025
Same author

Marginal integrity produced by quaternary ammonium methacrylate-based dental adhesive tested under physiologically relevant models.

Dental materials : official publication of the Academy of Dental Materials·2025
Same author

Acute Toxicities of Proton Craniospinal Irradiation in Pediatric Medulloblastoma: A Pediatric Proton/Photon Consortium Registry (PPCR) Study.

International journal of particle therapy·2025
Same journal

Embolization Followed by Self-Repositioning of a CardioMEMS™ Wireless Pulmonary Artery Hemodynamic Monitoring Sensor Device.

Methodist DeBakey cardiovascular journal·2026
Same journal

Anomalous Origin of the Vertebral Artery from Thyrocervical Trunk: A Rare Anatomical Variant.

Methodist DeBakey cardiovascular journal·2026
Same journal

Intra-atrial Baffling of an Infradiaphragmatic Scimitar Vein without Circulatory Arrest.

Methodist DeBakey cardiovascular journal·2026
Same journal

Value of Myocardial Strain in Assessing Cardiac Masses: A Case Report.

Methodist DeBakey cardiovascular journal·2026
Same journal

Transient Cortical Blindness and Hemi-Spatial Neglect Following Watchman Device Implantation.

Methodist DeBakey cardiovascular journal·2026
Same journal

Hemodynamics of Pericardial Constriction: Role of Echocardiography and Cardiac Catheterization.

Methodist DeBakey cardiovascular journal·2026
See all related articles

Related Experiment Video

Updated: May 26, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Nephrogenic calcific arteriopathy.

Juan Jose Olivero1, Juan Jorge Olivero, Peter Nguyen

  • 1Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, Texas, USA.

Methodist Debakey Cardiovascular Journal
|December 7, 2011
PubMed
Summary
This summary is machine-generated.

Vascular calcification is common in chronic kidney disease (CKD), causing serious health problems. Early intervention targeting underlying mechanisms can prevent these severe complications in CKD patients.

More Related Videos

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model
05:14

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

Published on: November 18, 2022

Related Experiment Videos

Last Updated: May 26, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model
05:14

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

Published on: November 18, 2022

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Pathophysiology

Background:

  • Vascular calcification is a prevalent complication in chronic kidney disease (CKD), significantly increasing patient morbidity and mortality.
  • The development of calcification is multifactorial, involving factors like calcium-phosphorus imbalance, inflammation, and hormonal dysregulation.
  • Beyond vasculature, CKD patients are susceptible to calcifications in heart valves, myocardium, and lungs, often with fatal outcomes.

Purpose of the Study:

  • To elucidate the complex pathogenesis of vascular and extraskeletal calcification in chronic kidney disease.
  • To highlight the significant clinical consequences associated with calcification in CKD patients.
  • To emphasize the potential for prevention through early intervention.

Main Methods:

  • Review of existing literature on the pathophysiology of calcification in CKD.
  • Analysis of factors contributing to vascular and extraskeletal calcification.
  • Identification of potential targets for therapeutic intervention.

Main Results:

  • CKD-associated calcification involves complex interactions of metabolic, hormonal, and inflammatory pathways.
  • Calcification contributes to severe cardiovascular events and other debilitating conditions in CKD.
  • Deficiencies in calcification inhibitors exacerbate the process.

Conclusions:

  • Vascular and extraskeletal calcification are major contributors to poor outcomes in CKD.
  • Understanding the multifactorial pathogenesis is key to developing preventive strategies.
  • Early detection and intervention targeting specific mechanisms can mitigate calcification-related complications in CKD.