Presence of Philadelphia (Ph) chromosome-negative cells in Ph-positive chronic myelogenous leukemia
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K Ohyashiki1, J H Ohyashiki, H Iwabuchi
1First Department of Internal Medicine, Tokyo Medical College, Japan.
Japanese Journal of Medicine
|January 1, 1990
Abstract:
Six cases of chronic myelogenous leukemia (CML) with coexistence of cells with a Philadelphia (Ph) translocation and a normal karyotype are described. Molecular analyses were performed in 3 of the 6 cases at two phases with different cytogenetic findings. Among the 6 cases, 4 cases were late appearance of a Ph chromosome. Two of the 3 patients analyzed had major breakpoint cluster region (Mbcr) rearrangements; aberrant Mbcr fragments were observed whether the cells had a Ph translocation or not. The remaining one did not show any rearrangements within the Mbcr DNA sequences.