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Inhibitory modulation of the reflex tracheal constriction induced by afferent vagal stimulation
M Misawa1, Y Takahashi, J Kamei
1Department of Applied Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
Japanese Journal of Pharmacology
|August 1, 1990
Abstract:
Afferent cervical vagal electrical stimulation caused a reflex tracheal constriction. Atropine changed the tracheal constriction into a tracheal dilatation that was almost inhibited by propranolol. In the hypertonic trachea with 5-hydroxytryptamine, a reflex dilatation following a constriction was observed by afferent vagal stimulation. The reflex dilatation was inhibited about 50% by propranolol and was abolished by hexamethonium. These results suggest that the adrenergic and nonadrenergic inhibitory innervations may mediate the reflex tracheal dilatation, especially in a hypertonic tracheal condition.