[Comparison of immunological aspects in diffuse panbronchiolitis and cystic bronchiectasis]
1Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi
|March 1, 1990
Summary
Diffuse panbronchiolitis (DPB) and cystic bronchiectasis (CBE) share similarities but exhibit distinct immune responses. DPB shows more impaired cell-mediated immunity, while both involve accelerated local humoral immunity.
Area of Science:
- Immunology
- Pulmonology
- Cell Biology
Background:
- Diffuse panbronchiolitis (DPB) and cystic bronchiectasis (CBE) are chronic respiratory diseases.
- Understanding their immunological underpinnings is crucial for differentiating and managing these conditions.
Purpose of the Study:
- To analyze the relationship between local immune responses and clinical outcomes in DPB and CBE patients.
- To compare immunological parameters between DPB and CBE to identify distinct disease characteristics.
Main Methods:
- Examined immunological parameters in 35 DPB patients and 20 CBE patients.
- Analyzed peripheral blood lymphocytes and lung tissue lymphocyte subsets.
- Assessed humoral immunity markers including IgA, IgG2, cold agglutinin, and rheumatoid factor.
Main Results:
- DPB patients exhibited more impaired cell-mediated immunity compared to CBE patients.
- Both diseases showed accelerated local humoral immunity with increased IgA and IgG2.
- Elevated CD4+ T-cells and Fc alpha R+ T-cells, with decreased Leu-11+ cells, were observed in peripheral blood.
- Lung tissue analysis in DPB revealed CD4+ T-cell dominance and abundant secretory IgA+ B-cells in bronchioles.
Conclusions:
- DPB and CBE may represent a spectrum of chronic respiratory infection linked to mucociliary dysfunction, often complicated by sinusitis and immune abnormalities.
- Despite similarities, distinct differences in systemic and local immune responses exist between DPB and CBE, likely influenced by disease-specific factors.
- Immunological fluctuations normalized with chemotherapy, indicating a link between inflammation and immune status.
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