Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Staphylococcal Skin Infections

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...

Clinical Significance of Antibiotic Resistance

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

Mechanism of Antibiotic Resistance in MRSA

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Darwin and the biological rhythms.

PNAS nexus·2024

Same author

Intranasally administered human MSC-derived extracellular vesicles inhibit NLRP3-p38/MAPK signaling after TBI and prevent chronic brain dysfunction.

Brain, behavior, and immunity·2022

Same author

The effect of caffeine on exercise performance is not influenced by ADORA2A genotypes, alone or pooled with CYP1A2 genotypes, in adolescent athletes.

European journal of nutrition·2022

Same author

First evaluation of the anxiolytic-like effects of a bromazepam‑palladium complex in mice.

Journal of inorganic biochemistry·2022

Same author

Revisiting the clinical impact of variants in EFHC1 in patients with different phenotypes of genetic generalized epilepsy.

Epilepsy & behavior : E&B·2020

Same author

Caffeine improves various aspects of athletic performance in adolescents independent of their 163 C > A CYP1A2 genotypes.

Scandinavian journal of medicine & science in sports·2020

Same journal

Detection of an O1 Vibrio cholerae Strain in the Blood of a Patient with Acute Cholangitis: A Rare Case Report.

The new microbiologica·2026

Same journal

A case of Kocuria rhizophila infection and persistence in ascitic fluid of a peritoneal dialysis patient with polycystic kidney disease.

The new microbiologica·2026

Same journal

Multiple-site venous thromboembolism in acute toxoplasmosis: report of two cases.

The new microbiologica·2026

Same journal

Comparative characteristics of the microbiota of diverticula in complicated diverticulitis.

The new microbiologica·2026

Same journal

A new subtype of hepatitis E virus gene 3 has emerged in Italy and several other European countries.

The new microbiologica·2026

Same journal

Microbiological Screening of Bacterial contamination of Platelet Concentrates units: a single center observational study.

The new microbiologica·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 26, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Wound infection by multiresistant Staphylococcus sciuri identified by molecular methods.

Daniel G Coimbra¹, Alda G C S Almeida, Jorge B O Jùnior

¹Universidade Federal de Alagoas, Bom Sucesso, Arapiraca-Alagoas, Brasil.

The New Microbiologica

|December 7, 2011

Summary

This summary is machine-generated.

A multidrug-resistant Staphylococcus sciuri strain caused a severe wound infection in Brazil. This methicillin-resistant Staphylococcus required limb amputation due to limited treatment options.

Related Experiment Videos

Last Updated: May 26, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Area of Science:

Microbiology
Infectious Diseases
Genetics

Background:

Wound infections pose significant clinical challenges, particularly those caused by antibiotic-resistant bacteria.
The emergence of multidrug-resistant organisms (MDROs) necessitates advanced diagnostic and therapeutic strategies.

Observation:

A case of severe wound infection was reported in a trauma patient in Agreste Alagoas, Brazil.
The causative agent was identified as multidrug-resistant Staphylococcus sciuri.

Findings:

Broad-spectrum PCR and 16S rDNA gene sequencing confirmed the presence of Staphylococcus sciuri.
The isolate exhibited high-level resistance to multiple antibiotics, classifying it as methicillin-resistant Staphylococcus.
Sensitivity was observed only to vancomycin and chloramphenicol.

Implications:

This case highlights the potential for rare Staphylococcus species to cause severe, resistant infections.
The limited antibiotic susceptibility underscores the need for vigilant surveillance and development of novel antimicrobial agents.
Severe infections may necessitate drastic measures such as limb amputation, impacting patient quality of life.