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Changes in inflammatory biomarkers after successful lifestyle intervention in obese children
Barbara Garanty-Bogacka1, Małgorzata Syrenicz, Joanna Goral
1Independent Laboratory of Propaedeutics of Children’s Diseases, Pomeranian Medical University, Szczecin, Poland. propedeutyka1@wp.pl
Insights
Weight loss in obese children and adolescents through lifestyle changes significantly reduces inflammation markers. This intervention improves metabolic health and cardiovascular risk factors, highlighting the importance of diet and exercise.
Area of Science:
- Pediatric Endocrinology
- Metabolic Syndrome Research
- Inflammation Biology
Background:
- Obesity is linked to chronic low-grade inflammation, increasing risks for insulin resistance, type 2 diabetes, dyslipidemia, and cardiovascular disease.
- Lifestyle interventions, including diet and exercise, are effective for managing obesity and associated health issues.
Purpose of the Study:
- To evaluate the impact of a six-month lifestyle modification program on serum inflammatory markers in obese children and adolescents.
- To assess changes in metabolic parameters and cardiovascular risk factors following weight reduction.
Main Methods:
- Fifty obese subjects participated in a program combining a hypocaloric diet and moderate physical activity for six months.
- Measurements included high-sensitive C-reactive protein (CRP), interleukin-6 (IL-6), fibrinogen, white blood count (WBC), glucose, insulin, HOMA-IR, HbA(1c), lipids, and blood pressure (SBP, DBP) pre- and post-intervention.
Main Results:
- Average weight loss was 5.3 ± 3.4 kg, with significant reductions in BMI, body fat percentage, waist circumference, SBP, DBP, HOMA-IR, and HbA(1c).
- Serum levels of IL-6, CRP, WBC, and fibrinogen decreased significantly post-intervention.
- Changes in body fat percentage and HOMA-IR were positively correlated with improvements in inflammatory markers.
Conclusions:
- Weight reduction achieved through lifestyle intervention effectively improves blood inflammatory markers in obese pediatric populations.
- This study underscores the benefits of lifestyle modifications in mitigating inflammation and metabolic dysfunction associated with childhood obesity.
Background:
Obesity has been associated with low-grade systemic inflammation, potentially leading to insulin resistance, type 2 diabetes, dyslipidemia, and cardiovascular diseases. Even moderate weight loss through dietary changes and physical exercise is effective in preventing and managing obesity-associated disorders. The aim of this study was to determine the effect of weight loss in response to a lifestyle modification on the serum levels of inflammatory markers in obese children and adolescents.
Material And Methods:
Fifty obese subjects completed a six-month programme consisting of combined hypocaloric diet and moderate physical activity. High-sensitive C-reactive protein (CRP), interleukin-6 (IL-6), fibrinogen (FB), white blood count (WBC), glucose, insulin, insulin resistance index (HOMA IR), glycosylated haemoglobin (HbA(1c)), lipids as well as systolic (SBP) and diastolic blood pressure (DBP) were measured before and after intervention.
Results:
Patients had a 5.3 ± 3.4 kg average weight loss, with significant decreases of SDS-BMI, percentage of body fat, SDS-waist, SBP and DBP, HOMA-IR, HbA(1c) and reductions in serum IL-6, CRP, WBC, FB. In the multivariable linear models, changes in percentage of body fat and HOMA-IR were positively associated with favourable changes in inflammatory parameters.
Conclusion:
This study demonstrates that weight reduction after successful lifestyle intervention results in improvements of blood inflammatory markers in obese children and adolescents.
