Related Experiment Video
Updated: May 26, 2026
07:26
Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
Published on: January 31, 2025
Hedgehog signalling in gut development, physiology and cancer
1Internal Medicine, 109 Zina Pitcher PL, BSRB, 2051, University of Michigan, Ann Arbor, MI 48105-2200, USA. merchanj@umich.edu
The Journal of Physiology
|December 7, 2011
Summary
The Hedgehog pathway, particularly sonic hedgehog, plays a role in stomach function and cancer. This review explores its impact on gastrointestinal physiology and neoplasia.
Area of Science:
- Cellular biology
- Gastroenterology
- Oncology
Background:
- The Hedgehog pathway is a crucial signal transduction pathway in mammalian cells, primarily studied for its developmental roles.
- Recent research highlights its involvement in adult tissues due to activation during proliferation and neoplastic transformation.
- Sonic hedgehog is significantly expressed in the gastric mucosa, indicating a potential role in stomach physiology and disease.
Purpose of the Study:
- To review and synthesize current knowledge of the Hedgehog pathway.
- To elucidate the pathway's role in gastrointestinal physiology, using the stomach as a model.
- To explore the pathway's involvement in gastric neoplasia.
Main Methods:
- Literature review of studies on the Hedgehog pathway.
- Analysis of research on sonic hedgehog expression in the gastric mucosa.
- Synthesis of findings related to gastrointestinal organogenesis, acid secretion, and cancer.
Main Results:
- The Hedgehog pathway is implicated in both normal stomach function and the development of gastric cancer.
- Sonic hedgehog signaling is a key factor in gastric mucosal physiology.
- Dysregulation of this pathway contributes to neoplastic transformation in the stomach.
Conclusions:
- Understanding the Hedgehog pathway is vital for comprehending gastrointestinal physiology.
- Targeting the Hedgehog pathway may offer new therapeutic strategies for gastric cancer.
- Further research is warranted to fully elucidate the pathway's complex roles in the gastrointestinal tract.
More Related Videos
Related Concept Videos
02:33Hedgehog Signaling Pathway
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
02:33Hedgehog Signaling Pathway
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
01:22Microtubules in Signaling
The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...