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Updated: May 26, 2026

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

GenBank.

Dennis A Benson¹, Ilene Karsch-Mizrachi, Karen Clark

¹National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.

Nucleic Acids Research

|December 7, 2011

Summary

This summary is machine-generated.

GenBank is a vital nucleotide sequence database for over 250,000 species, sourced from diverse sequencing projects. It ensures global data coverage through daily exchanges with international archives.

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Creation and Maintenance of a Living Biobank - How We Do It

Creation and Maintenance of a Living Biobank - How We Do It

Published on: April 10, 2021

Area of Science:

Bioinformatics
Genomics
Molecular Biology

Background:

GenBank is a primary public repository for nucleotide sequences.
It archives data from individual labs and large-scale sequencing initiatives.
Global data synchronization is maintained with ENA and DDBJ.

Purpose of the Study:

To describe the GenBank database and its content.
To outline data submission and access methods.
To highlight GenBank's integration within the NCBI ecosystem.

Main Methods:

Data acquisition through laboratory and project submissions (e.g., whole-genome shotgun).
Use of submission tools like BankIt and Sequin.
Daily data exchange with European Nucleotide Archive (ENA) and DNA Data Bank of Japan (DDBJ).

Main Results:

GenBank houses sequences from over 250,000 formally described species.
Accession numbers are assigned by GenBank staff.
Database is accessible via NCBI Entrez, integrating diverse biological data.

Conclusions:

GenBank is a comprehensive, globally synchronized nucleotide sequence resource.
It facilitates biological research through integrated data access and search tools like BLAST.
Regular updates and FTP access ensure data availability.