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Related Concept Videos

Surface Tension and Surface Energy01:16

Surface Tension and Surface Energy

When a paint brush is immersed in water, the bristles wave freely inside the water. When it is taken out, the bristles stick together. The reason behind this effect is surface tension.
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Surface Active Agents01:27

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Surfactants, named for their behavior at interfaces, positively adsorb at the interfaces of two phases, reducing interfacial tension. Their versatility as emulsifiers, detergents, and foaming agents stems from this ability. Surfactants, often termed amphiphiles, share the property of amphipathy, with molecules having both hydrophilic and hydrophobic portions. The hydrophilic part is called the head, and the hydrophobic part, including an elongated alkyl substituent, forms the tail.Surfactants...
Surface Tension01:24

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Surface tension is defined as the force per unit length (γ) acting along the surface of a liquid. It arises due to strong intermolecular forces of attraction. A molecule located inside the bulk of the liquid is surrounded by other molecules and experiences equal forces in all directions. However, a molecule at the surface experiences unbalanced forces because there are more neighboring molecules below than above. This creates a net inward force that pulls surface molecules toward the interior,...

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The Evolution of Silica Nanoparticle-polyester Coatings on Surfaces Exposed to Sunlight
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Published on: October 11, 2016

Protein surface characterization using an invariant descriptor.

Zainab Abu Deeb1, Donald A Adjeroh, Bing-Hua Jiang

  • 1Lane Department of Computer Science and Electrical Engineering, West Virginia University, Morgantown, WV 26506, USA.

International Journal of Biomedical Imaging
|December 7, 2011
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel protein surface descriptor using residue-specific distance distributions. This method enhances protein classification and database searching, improving the retrieval of related protein families.

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Area of Science:

  • Biochemistry
  • Structural Biology
  • Bioinformatics

Background:

  • Characterizing protein surfaces is crucial for understanding protein function and interactions.
  • Existing methods for protein surface analysis have limitations in accuracy and scalability.

Purpose of the Study:

  • To develop a new invariant descriptor for protein surface characterization.
  • To enable effective protein functional classification and database searching.

Main Methods:

  • A local descriptor was created for circular patches on protein surfaces, recording residue-specific distance distributions and pairwise residue co-occurrences.
  • A global descriptor was constructed by combining local descriptors for the entire protein surface.

Main Results:

  • The new descriptor demonstrated effectiveness in protein classification and retrieval tasks for three protein families.
  • Precision and recall improved when incorporating residue co-occurrences, with an area under the curve ranging from 0.6494 to 0.6683.
  • Large-scale screening successfully ranked related family members at the top and retrieved uncharacterized proteins.

Conclusions:

  • The proposed residue-distance co-occurrence based descriptor offers a novel and effective approach for protein surface analysis.
  • This method shows promise for improving protein functional classification and large-scale protein database searching.