Identification of major degradation products of ketoconazole
Rajendra A Mhaske1, Shirish Sahasrabudhe
1Sharon Bio Medicine, 312, C-Wing, BSEL Tech Park, Opp. Vashi Railway Station, Sector 30 (A), Vashi, Navi-Mumbai-400703, India.
Abstract:
Analytical methods were developed for the identification of major degradation products of Ketoconazole, an antifungal agent. The stressed degradation of Ketoconazole drug substance was performed under acid, base, thermal, photo and oxidative stress conditions. The major degradation was observed under acid, base and oxidative stress conditions. The degradation study was performed on Inertsil ODS-3V, length 100 X diameter 4.6 mm, particle size 3 μm column using gradient method. These degradants were identified by LC-MS technique.
More Related Videos
10:49Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling
Published on: September 20, 2016
10:51Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
Published on: November 15, 2013
Related Concept Videos
Mass Spectrometry: Aldehyde and Ketone Fragmentation
Phase I Reactions: Reductive Reactions
NMR Spectroscopy and Mass Spectrometry of Aldehydes and Ketones
Phase I Reactions: Oxidation of Aliphatic and Aromatic Carbon-Containing Systems
Oxidation reactions are fundamental in aromatic carbon-containing systems. An example is the hydroxylation of phenobarbital, a process that transforms it into...
Loss of Carboxy Group as CO2: Decarboxylation of β-Ketoacids
Keto–Enol Tautomerism: Mechanism
