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Updated: May 26, 2026

Operation of the Collaborative Composite Manufacturing (CCM) System
Published on: October 1, 2019
[Carney complex]
D Kacerovská1, M Michal, R Síma
1Siklův potologický ústav, FN a LF UK, Plzen. kacerovska@medima.cz
Abstract:
Carney complex is a clinically and genetically heterogeneous disease, with at least two genetic loci including the PRKAR1A gene located on chromosome 17 and the CNC2 locus mapped to chromosome 2. Clinically this syndrome is characterized by multiple myxomas occurring in different anatomic sites, mucocutaneous pigmentary lesions, and a variety of non-endocrine and endocrine tumors, often causing endocrine abnormalities, involving various organs. Knowledge of morphological findings in CNC patients with their typical locations is necessary to raise suspicion of this syndrome by pathologists. Confirmation of the diagnosis allows regular clinical check-ups and early treatment of these patients.
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