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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

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Related Experiment Video

Updated: May 26, 2026

Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10
10:42

Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10

Published on: November 19, 2016

Mite allergens: an overview.

J C Bessot1, G Pauli

  • 1Ariale, Bâtiment Ancienne Ophtalmologie, Hôpital Civil, Strasbourg Cedex, France. jcbessot@cegetel.net

European Annals of Allergy and Clinical Immunology
|December 8, 2011
PubMed
Summary
This summary is machine-generated.

Mite allergens, particularly Der p 1 and Der p 2 from the Pyroglyphidae family, are primary causes of asthma. Understanding their molecular structures aids in diagnosis and developing new hypoallergenic immunotherapies.

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Related Experiment Videos

Last Updated: May 26, 2026

Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10
10:42

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Published on: November 19, 2016

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

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Published on: March 3, 2023

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Area of Science:

  • Immunology
  • Allergology
  • Molecular Biology

Background:

  • Mite allergens from the Pyroglyphidae family are significant triggers for perennial asthma and rhinitis.
  • Molecular characterization of these allergens has advanced significantly since 1988.
  • Der p 1 and Der p 2 are major allergens, recognized by over 80% of allergic patients in Europe.

Purpose of the Study:

  • To review the molecular understanding of Pyroglyphidae mite allergens.
  • To discuss the implications of allergen structure on cross-reactivity and diagnosis.
  • To explore novel immunotherapy strategies based on molecular insights.

Main Methods:

  • Analysis of amino acid sequences and tertiary structures of mite allergens.
  • Review of molecular epidemiology data for diagnostic applications.
  • Examination of structural homologies, such as Der p 2 with MD-2.

Main Results:

  • Most of the 22 identified mite allergens have known structures and functions.
  • Der p 1 (cysteine protease) and Der p 2 (MD-2 homology) are key allergens.
  • Molecular knowledge improves understanding of cross-reactivity and aids diagnostic marker selection.

Conclusions:

  • Structural elucidation of mite allergens enhances the interpretation of allergic cross-reactivity.
  • Molecular epidemiology guides the selection of diagnostic allergens.
  • Genetically engineered hypoallergenic variants offer promising avenues for future mite allergen immunotherapy.