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Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
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Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays

Published on: January 7, 2016

Insulin-like growth factor-1 (IGF-1) serum concentration among 7-year-old extremely low birth weight children--an

Przemko Kwinta1, Małgorzata Klimek, Małgorzata Wójcik

  • 1Department of Pediatrics, Jagiellonian University Medical College, Cracow, Poland. kwintap@mp.pl

Journal of Pediatric Endocrinology & Metabolism : JPEM
|December 8, 2011
PubMed

Insights

Short stature affects similar percentages of appropriate-for-gestational-age (AGA) and small-for-gestational-age (SGA) extremely low birth weight (ELBW) children at age 7. Lower weight and insulin growth factor-1 (IGF-1) levels are seen in short-stature ELBW children, indicating IGF-1

Area of Science:

  • Pediatric Endocrinology
  • Neonatology
  • Growth and Development

Background:

  • Extremely low birth weight (ELBW) infants are at risk for altered somatic development and metabolic profiles.
  • Comparison of growth trajectories and metabolic markers between small-for-gestational-age (SGA) and appropriate-for-gestational-age (AGA) ELBW children is crucial.

Purpose of the Study:

  • To compare somatic development, body composition, insulin growth factor-1 (IGF-1) serum concentration, and lipid profiles in 7-year-old SGA and AGA ELBW children versus full-term (FT) controls.
  • To investigate the role of IGF-1 in growth restriction among ELBW survivors.

Main Methods:

  • Evaluated 57 AGA ELBW, 24 SGA ELBW children, and 37 age- and sex-matched FT controls.
  • Assessed somatic development (height, weight, head circumference), body composition (triceps skin fold, BMI), serum IGF-1, and lipid profiles.

Main Results:

  • Short stature (< 3rd percentile) occurred in similar proportions of AGA and SGA ELBW children.
  • Short-stature ELBW children (both AGA and SGA) exhibited significantly lower weight and IGF-1 levels compared to normal-stature peers.
  • SGA short-stature children also showed significantly higher total and LDL cholesterol levels.

Conclusions:

  • Short stature is prevalent in both AGA and SGA ELBW survivors at age 7.
  • Significantly lower weight and IGF-1 levels in short-stature ELBW children suggest IGF-1's involvement in prolonged growth restriction.
  • These findings highlight the importance of monitoring growth and IGF-1 in ELBW populations.
Abstract

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