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Acanthosis nigricans and truncal fat in overweight and obese children

Gal Dubnov-Raz1, Ram Weiss, Raanan Raz

  • 1Exercise, Nutrition, and Lifestyle Clinic, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel. gal.dubnov-raz@sheba.health.gov.il

Journal of Pediatric Endocrinology & Metabolism : JPEM
|December 8, 2011
PubMed

Insights

Acanthosis nigricans (AcN) in overweight children is linked to greater overall adiposity. However, after adjusting for BMI, central obesity is not significantly increased in children with AcN.

Area of Science:

  • Pediatric Endocrinology
  • Dermatology
  • Obesity Research

Background:

  • Screening for acanthosis nigricans (AcN) is recommended in overweight children.
  • The clinical significance of AcN and its association with central obesity in pediatric populations remains unclear.

Purpose of the Study:

  • To compare anthropometric and clinical parameters related to adiposity in overweight and obese children, with and without AcN.
  • To investigate the relationship between AcN and central obesity markers in children.

Main Methods:

  • One hundred forty-nine overweight and obese children were assessed for AcN.
  • Measurements included height, weight, waist and hip circumferences, triceps skinfold thickness, and segmental body fat analysis.

Main Results:

  • Acanthosis nigricans (AcN) was identified in 14.8% of the children studied.
  • Children with AcN exhibited significantly higher height, weight, BMI, waist circumference, waist-to-height ratio, triceps skinfold thickness, and total and truncal body fat percentage compared to those without AcN.
  • After adjusting for age and BMI, no specific adiposity measure remained significantly increased in children with AcN.

Conclusions:

  • Overweight and obese children with AcN generally present with greater overall and central adiposity compared to their peers without AcN.
  • Analysis adjusting for BMI indicates no conclusive evidence of increased abdominal fat in overweight and obese children with AcN.
Abstract

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