Related Experiment Video
Updated: May 26, 2026
05:30
Cercarial Transformation and in vitro Cultivation of Schistosoma mansoni Schistosomules
Published on: August 16, 2011
Recent advances in Schistosoma genomics.
M M Mourão1, C Grunau, P T LoVerde
1Genomics and Computational Biology Group, Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz - FIOCRUZ, Belo Horizonte, MG, Brazil.
Parasite Immunology
|December 8, 2011
Summary
Schistosome genomics research is advancing control tools and understanding parasite biology. New functional genomics tools and epigenetic insights are key to future discoveries in schistosome research.
Area of Science:
- Parasitology
- Genomics
- Molecular Biology
Background:
- Schistosome research has entered the genomic era with the sequencing of Schistosoma mansoni and Schistosoma japonicum genomes.
- The primary motivation for schistosome genomics is the urgent need for novel control strategies against these parasitic flatworms.
Purpose of the Study:
- To review recent advancements in schistosome research, focusing on genomics.
- To discuss future perspectives integrating genomics, genetic mapping, epigenetics, and functional genomics tools.
Main Methods:
- Review of recent literature on schistosome genomics.
- Analysis of the impact of genetic mapping on genome assembly and research approaches.
- Exploration of epigenetic insights into schistosome biology.
- Discussion of emerging functional genomics tools for gene function studies.
Main Results:
- Schistosome genomics provides a foundation for developing new control tools.
- Genetic mapping has improved genome assembly and opened new research avenues.
- Epigenetics offers valuable insights into schistosome biology.
- New functional genomics tools enhance the understanding of parasite-specific genes.
Conclusions:
- Genomic advancements are crucial for understanding schistosome biology and developing control methods.
- Integrating genomics, genetic mapping, epigenetics, and functional genomics will drive future schistosome research.
- Further exploration of parasite- or taxon-specific genes is essential for targeted interventions.
Related Concept Videos
03:00Next-generation Sequencing
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
02:46Genetic Screens
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
02:02Genomics
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...