[Active methods of correction of endotoxemia in generalized suppurative infection]

The characteristics of the natural history of acute sepsis and the nature of the intoxication syndrome are analysed an on ample material (120 patients), and microbiological and immunological diagnostic findings are shown. Endotoxicosis in sepsis is attended by marked disorders of the immune status in the form of varying degrees of immunodeficiency. The authors generalize their experience with the management of endotoxicosis in sepsis. The article first shows the results of the combined use of various methods of endotoxicosis correction (homosorption, hemodiafiltration, plasmapheresis, endolymphatic therapy, ultraviolet irradiation of autoblood, hyperbaric oxygenation, application sorption) in the treatment of 120 patients with sepsis of various etiology. Active methods of detoxification via the blood and lymphatic system were first applied in the management of endotoxicosis in patients with sepsis.