Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Steel Manufacturing

Steel Manufacturing

Steel manufacturing is a multi-stage process that begins by smelting iron ore into cast iron in a blast furnace. This initial stage involves layering iron ore with coke, a type of fuel, and crushed limestone within the furnace. The coke is ignited with a high volume of air, leading to the creation of carbon monoxide, which acts to reduce the iron ore to pure iron.
During this smelting process, limestone plays a crucial role by forming slag. Slag captures impurities within the molten iron, such...

Olefin Metathesis Polymerization: Overview

Olefin Metathesis Polymerization: Overview

Recently, the development of olefin metathesis polymerization advanced the field of polymer synthesis. Simply put, the reorganization of substituents on their double bonds between two olefins in the presence of a catalyst is known as the olefin metathesis reaction. The use of metathesis reaction for polymer synthesis is called olefin metathesis polymerization.
Ruthenium-based Grubbs catalyst is the most commonly used catalyst for olefin metathesis polymerization. Grubbs catalyst consists of a...

Phase Transitions: Melting and Freezing

Phase Transitions: Melting and Freezing

Heating a crystalline solid increases the average energy of its atoms, molecules, or ions, and the solid gets hotter. At some point, the added energy becomes large enough to partially overcome the forces holding the molecules or ions of the solid in their fixed positions, and the solid begins the process of transitioning to the liquid state or melting. At this point, the temperature of the solid stops rising, despite the continual input of heat, and it remains constant until all of the solid is...

Upstream Processing

Upstream Processing

Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...

Types of Step-Growth Polymers: Polyesters

Types of Step-Growth Polymers: Polyesters

The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...

Structural Steel Products

Structural Steel Products

Structural steel products are created within a structural mill. The process begins with a beam blank that is reheated and then fed through a series of rollers. These rollers progressively shape the metal into its final form. Adjusting the spacings between the rollers allows for the production of different sections with the same nominal dimensions.
Once shaped, the steel's final form emerges as a continuous length, which is then segmented by a hot saw into manageable pieces. These segments are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Development of a pH-modulating vaginal film through direct powder extrusion 3D printing for on-demand, hormone-free contraception: a quality by design approach.

International journal of pharmaceutics·2026

Same author

Metabolic and bariatric surgery for patients with obesity type 1 diabetes mellitus: A comprehensive updated systematic review and meta-analysis.

Diabetic medicine : a journal of the British Diabetic Association·2026

Same author

Pediatric Central Diabetes Insipidus due to Arginine Vasopressin Deficiency in the Perianesthetic Period.

Paediatric anaesthesia·2026

Same author

Development of 3D-printed chitosan/p-coumaric acid scaffolds for wound healing: antibacterial properties and drug release kinetics.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2025

Same author

Twin-screw melt granulation of Eudragit® FS100: optimization of coating-free delayed-release matrix tablets with HPMC K4M modulation.

International journal of pharmaceutics·2025

Same author

Investigating the Potential of Poly(2-ethyl-2-oxazoline) and Its Polymer Blends for Enhancing Fenofibrate Amorphous Solid Dispersion Dissolution Profile.

Pharmaceutics·2025

Search research articles

Related Experiment Video

Updated: May 26, 2026

Fused Filament Fabrication (FFF) of Metal-Ceramic Components

Fused Filament Fabrication (FFF) of Metal-Ceramic Components

Published on: January 11, 2019

Melt extrusion: process to product.

Michael A Repka¹, Sejal Shah, Jiannan Lu

¹The University of Mississippi, School of Pharmacy, Department of Pharmaceutics, University, MS 38677, USA. marepka@olemiss.edu

Expert Opinion on Drug Delivery

|December 8, 2011

Summary

This summary is machine-generated.

Hot melt extrusion (HME) is a key pharmaceutical technology for improving the bioavailability of poorly soluble drugs. This versatile technique offers solutions for various drug delivery challenges, from oral to transdermal applications.

More Related Videos

Film Extrusion of Crambe abyssinica/Wheat Gluten Blends

Film Extrusion of Crambe abyssinica/Wheat Gluten Blends

Published on: January 17, 2017

A Soft Tooling Process Chain for Injection Molding of a 3D Component with Micro Pillars

A Soft Tooling Process Chain for Injection Molding of a 3D Component with Micro Pillars

Published on: August 4, 2018

Related Experiment Videos

Last Updated: May 26, 2026

Fused Filament Fabrication (FFF) of Metal-Ceramic Components

Fused Filament Fabrication (FFF) of Metal-Ceramic Components

Published on: January 11, 2019

Film Extrusion of Crambe abyssinica/Wheat Gluten Blends

Film Extrusion of Crambe abyssinica/Wheat Gluten Blends

Published on: January 17, 2017

A Soft Tooling Process Chain for Injection Molding of a 3D Component with Micro Pillars

A Soft Tooling Process Chain for Injection Molding of a 3D Component with Micro Pillars

Published on: August 4, 2018

Area of Science:

Pharmaceutical Technology
Drug Delivery Systems
Materials Science

Background:

Hot melt extrusion (HME) is widely accepted in pharmaceutical research and manufacturing.
Over 50% of new drug candidates are lipophilic with poor bioavailability.
HME addresses formulation and processing challenges for these drugs.

Purpose of the Study:

To provide a holistic review of hot melt extrusion (HME) technology.
To explore HME's applications in various drug delivery systems.
To highlight HME's role in overcoming bioavailability issues.

Main Methods:

Review of literature on HME equipment, processing, and materials.
Analysis of HME applications in oral, mucosal, dermal, and other delivery routes.
Examination of HME for developing solid molecular dispersions.

Main Results:

HME demonstrates viability for sustained, modified, and targeted drug delivery.
Successful applications include immediate release, taste masking, and enteric delivery.
HME enhances drug bioavailability through improved solubility and dissolution.

Conclusions:

Interest in HME for pharmaceutical processes is growing.
HME offers potential for automation, reducing costs and investment.
HME is a necessary consideration for advanced drug delivery solutions.