Preoperative chemotherapy with doxorubicin in Wilms tumor

Vincristine and actinomycin-D have long been used as the preoperative chemotherapy before nephrectomy in patients with Wilms tumor (WT). Actinomycin-D is not readily found in Turkey, and delay in treatment, occurring basically from commercial and marketing problems, prompted us to administer alternatives such as doxorubicin, another antitumor antibiotic available in Turkey, to our newly diagnosed patients with WT.

Between November 2009 and January 2011, 12 consecutive patients with WT were included in the study. Preoperative chemotherapy consisted of vincristine (1.4 mg/m, days 1, 8, 15, and 22) and doxorubicin (20 mg/m, 1 to 3 d).

All renal tumors showed shrinkage drastically after 4 weeks of preoperative chemotherapy. Surgery of all the patients was uneventful and without any complications. At the end of the median follow-up time of 8 months (range, 6 to 17 mo), all patients are in remission without a sign of the disease.

Preoperative chemotherapy consisting of vincristine and doxorubicin seems to be successful as a preoperative treatment in achieving shrinkage and reducing the risk of surgical complications. On the basis of the promising results in our study, it is worth administering a similar regimen with further follow-up in larger populations.