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Published on: November 28, 2018
Mean platelet volume is increased in patients with bicuspid aortic valve
Emine Bilen1, Ibrahim Halil Tanboga, Mustafa Kurt
1Ankara Ataturk Education and Research Hospital, Ankara, Turkey.
Background:
It has been demonstrated that platelet activation occurs in patients with aortic stenosis. However, no study has assessed platelet activation in patients with a normally functioning bicuspid aortic valve (BAV). Therefore, we aimed to investigate relationship between platelet activation assessed by mean platelet volume (MPV) and normally functioning BAV.
Methods:
Thirty-nine patients with isolated BAV and 25 age- and gender-matched healthy participants were included in the study. Patients with more than mild aortic regurgitation and aortic velocity >2 m/s were excluded from the study. For the entire study population, MPV was measured using an automatic blood counter.
Results:
Compared to control group, MPV value was significantly higher in patients with BAV (8.6 ± 1.0 vs 8.0 ± 0.8, p: .01). In the correlation analysis, there was a significant correlation between MPV measures with aortic stiffness (r: .32 and p: .01) and aortic elastic modulus (r: .37 and p: .003).
Conclusion:
Our study results indicate that BAV is associated with elevated MPV values.
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