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Analysis of Craniomaxillofacial Malformations in Mice Using Three-dimensional Microcomputed Tomography
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3-dimensional imaging modalities for phenotyping genetically engineered mice.

K A Powell1, D Wilson

  • 1Small Animal Imaging Shared Resource, The James Comprehensive Cancer Center Department of Biomedical Informatics, Ohio State University, Columbus, Ohio, USA. kimerly.powell@osumc.edu

Veterinary Pathology
|December 8, 2011
PubMed
Summary
This summary is machine-generated.

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Advanced 3D imaging techniques like magnetic resonance microscopy (MRM) and microCT enable detailed whole-body phenotyping of genetically engineered mice. These methods offer high-resolution structural and functional insights for both embryos and adults.

Area of Science:

  • Biomedical Imaging
  • Genetically Engineered Mouse Models
  • High-Resolution Imaging

Background:

  • Genetically engineered mice are crucial for disease modeling.
  • Comprehensive phenotyping is essential for understanding gene function and disease.
  • Existing imaging methods have limitations in resolution and scope.

Purpose of the Study:

  • To review and compare various 3D digital imaging modalities for whole-body mouse phenotyping.
  • To highlight the capabilities of different techniques for structural and functional assessment.
  • To discuss advancements in automated data acquisition and high-throughput phenotyping.

Main Methods:

  • Magnetic Resonance Microscopy (MRM)
  • X-ray Microcomputed Tomography (microCT)

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Related Experiment Videos

Last Updated: May 26, 2026

Analysis of Craniomaxillofacial Malformations in Mice Using Three-dimensional Microcomputed Tomography
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Published on: January 17, 2025

Multiple-mouse Neuroanatomical Magnetic Resonance Imaging
09:08

Multiple-mouse Neuroanatomical Magnetic Resonance Imaging

Published on: February 27, 2011

Rapid Acquisition of 3D Images Using High-resolution Episcopic Microscopy
07:27

Rapid Acquisition of 3D Images Using High-resolution Episcopic Microscopy

Published on: November 21, 2016

  • Optical Projection Tomography (OPT)
  • Episcopic and Cryoimaging
  • Ultrasound Biomicroscopy (UBM)

    • Main Results:

    • MRM and microCT excel at organ-level structural analysis.
    • Episcopic and OPT imaging provide cellular-level structural and molecular fluorescence data.
    • UBM allows longitudinal in utero embryonic development monitoring.
    • Specimen preparation minimally alters samples, preserving native orientation.

    Conclusions:

    • A diverse range of 3D imaging modalities allows for detailed phenotyping of genetically engineered mice at microscopy resolution.
    • These techniques provide valuable structural and functional information from molecular to organ levels.
    • Ongoing technological advancements are driving improvements in automated data acquisition and high-throughput phenotyping.