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Updated: May 26, 2026

Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete
Published on: January 24, 2025
[Unusual faces of syphilis]
S C Sammet1, A Niedermeier, J Bogner
1Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilans-Universität München, Frauenlobstr. 9-11, 80337, München, Deutschland. stefanie.sammet@med.uni-muenchen.de
Abstract:
The challenging "great masquerader" is resurgent! For several years syphilis has shown an increasing incidence across Europe and its variable manifestations necessitate its inclusion amongst many differential diagnoses. Using serological tests, it is possible to accurately diagnose syphilis, initiate stage-appropriate therapy and exclude co-infections. In this article, we feature nine unusual presentations of secondary syphilis. In four cases, serology confirmed HIV co-infection.
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Unusual Results
According to the range rule of thumb, any value above or below two standard deviations, 2σ from the mean, μ is considered unusual.
Maximum unusual value = μ + 2σ
Minimum unusual value...

