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Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases
Published on: December 6, 2016
Livedoid vasculopathy: an intringuing cutaneous disease
Paulo Ricardo Criado1, Evandro Ararigboia Rivitti, Mirian Nacagami Sotto
1Divisão de Dermatologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Brasil. prcriado@uol.com.br
Anais Brasileiros De Dermatologia
|December 8, 2011
Summary
Livedoid vasculopathy is a rare skin condition causing painful leg ulcers and atrophie blanche. This review explores its causes, like thrombophilia, and treatment options for this challenging disease.
Area of Science:
- Dermatology
- Vascular Medicine
- Pathology
Background:
- Livedoid vasculopathy is a chronic skin condition characterized by purpuric lesions and painful ulcerations on the lower extremities.
- It is often pauciinflammatory or non-inflammatory, leading to characteristic atrophie blanche scars.
- The exact etiology remains unclear, but associations with thrombophilia are frequently observed.
Purpose of the Study:
- To review the current literature on livedoid vasculopathy.
- To explore the etiopathogenic associations, focusing on thrombophilia.
- To summarize histopathological findings and therapeutic strategies for managing this condition.
Main Methods:
- Comprehensive literature search of medical databases for studies and case reports on livedoid vasculopathy.
- Analysis of identified articles focusing on disease associations, histopathology, and treatment outcomes.
- Synthesis of findings to provide an overview of the current understanding and management.
Main Results:
- Livedoid vasculopathy is linked to various thrombophilic states, including inherited and acquired conditions.
- Histopathological examination often reveals dermal vessel occlusion without significant inflammation.
- Treatment is challenging, with varying success rates for anticoagulation, antiplatelet agents, and other therapies.
Conclusions:
- Thrombophilia is a significant contributing factor in many cases of livedoid vasculopathy.
- Accurate diagnosis and understanding of underlying causes are crucial for effective management.
- Multifaceted therapeutic approaches are often required to address the complex nature of this disease.
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