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Related Experiment Video

Updated: May 26, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Cutaneous leiomyosarcoma on the trunk.

Marisa Carpinteiro André¹, Joana Veiga Antunes, Miguel Duarte Reis

¹Clínica Universitária de Dermatologia, Hospital de Santa Maria, Lisboa, Portugal. marisa.andre@netc.pt

Anais Brasileiros De Dermatologia

|December 8, 2011

Summary

This summary is machine-generated.

This case report details a rare dermal leiomyosarcoma in a 57-year-old male. Surgical removal was successful for this malignant spindle cell tumor.

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Last Updated: May 26, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

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Published on: May 17, 2024

Area of Science:

Dermatology
Oncology
Pathology

Background:

Cutaneous leiomyosarcoma is a rare soft tissue sarcoma, representing 7% of all cases.
Typically affects males aged 50-70, with trunkal presentation in 10-15% of instances.
Potential risk factors include radiotherapy and prior trauma.

Observation:

A 57-year-old male presented with an eight-month history of a firm, painless, erythematous-violaceous dermal tumor.
The tumor was located on the presternal region and extended through the entire dermal thickness.
Histopathology revealed a malignant spindle cell neoplasm with pleomorphic nuclei and high mitotic activity.

Findings:

Immunohistochemical analysis confirmed the diagnosis of dermal leiomyosarcoma.
Tumor cells stained positive for smooth muscle actin, desmin, and vimentin.
Staining was negative for S-100 protein and pan-cytokeratin, ruling out other differential diagnoses.

Implications:

This case highlights the importance of considering rare cutaneous malignancies.
Radical surgical excision is a primary treatment modality for localized dermal leiomyosarcoma.
Accurate histopathological and immunohistochemical evaluation is crucial for diagnosis and management.