Related Experiment Video
Updated: May 26, 2026

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
Do you know this syndrome? Chediak-Higashi syndrome
Giovana Tadéia Fantinato1, Silmara da Costa Pereira Cestari, João Paulo Junqueira Magalhães Afonso
1Departamento de Dermatologia, Universidade Federal de São Paulo, Brasil. giovanafantinato@uol.com.br
Abstract:
Chediak-Higashi syndrome is characterized by varying degrees of oculocutaneous albinism, recurrent infections, bleeding disorders and variable neurological involvement. The treatment consists of bone marrow transplantation, which corrects the immunologic and hematologic defects. Untreated patients die as the result of bacterial infections or develop "accelerated phase" lymphoproliferation. We present a case of Chediak-Higashi syndrome and discuss the clinical and laboratorial features that determine its diagnosis.
Related Concept Videos
Cohesins
Cohesin complexes in Meiotic Division
Meiosis involves two distinct rounds of chromosomal segregation and cell divisions— Meiosis I followed by Meiosis II – producing four daughter cells. Meiosis I includes the separation of homologous...
Nephrotic Syndrome I : Introduction
Karyotyping
Pedigree Analysis
Cushing Syndrome I: Introduction
Smooth Endoplasmic Reticulum
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
