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Related Experiment Video

Updated: May 26, 2026

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
09:24

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Published on: October 3, 2014

Engineering tissue with BioMEMS.

Jeffrey T Borenstein1, Gordana Vunjak-Novakovic

  • 1Biomedical Engineering Center, Draper Laboratory, Cambridge, Massachusetts, USA. jborenstein@draper.com

IEEE Pulse
|December 8, 2011
PubMed
Summary
This summary is machine-generated.

Microfluidic-BioMEMS platforms enhance tissue engineering by controlling cell environments, forming perfusable networks for vascularization, and enabling the study of functional tissue modules. This technology addresses key challenges in stem cell differentiation and tissue development.

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Last Updated: May 26, 2026

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
09:24

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Published on: October 3, 2014

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Published on: May 21, 2018

Magnetic Resonance Elastography Methodology for the Evaluation of Tissue Engineered Construct Growth
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Published on: February 9, 2012

Area of Science:

  • Biotechnology
  • Tissue Engineering
  • BioMEMS

Background:

  • Microfluidic-BioMEMS platforms offer precise control over cellular microenvironments.
  • These platforms are crucial for advancing tissue engineering applications.

Purpose of the Study:

  • To highlight the advantages of microfluidic-BioMEMS in tissue engineering.
  • To showcase how this technology addresses critical needs in the field.

Main Methods:

  • Utilizing microfluidic-BioMEMS for cell screening and environment control.
  • Employing microfluidic technology for creating perfusable networks.
  • Engineering and studying functional tissue modules using these devices.

Main Results:

  • Optimized cell sources for tissue engineering applications.
  • Formation of stable, perfusable networks for vascularized tissue engineering.
  • Development of models for liver sinusoids, kidney nephrons, and lung bronchioles.

Conclusions:

  • Microfluidic-BioMEMS platforms are versatile tools for tissue engineering.
  • The technology effectively addresses challenges in tissue vascularization, functional unit recapitulation, and stem cell differentiation.