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Prevalence of colorectal polyps in pediatric colonoscopy
Kalpesh Thakkar1, Abeer Alsarraj, Emily Fong
1The Section of Pediatric Gastroenterology, Hepatology and Nutrition, Texas Children's Hospital and Baylor College of Medicine, 6621 Fannin St CCC 1010, Houston, TX 77030, USA. kthakkar@bcm.tmc.edu
Insights
Colorectal polyps are found in 6.1% of pediatric colonoscopies, and in 12% of children with lower gastrointestinal bleeding. Juvenile polyps and adenomas constitute about 26% of these cases.
Area of Science:
- Pediatric Gastroenterology
- Colorectal Health
- Endoscopic Diagnostics
Background:
- Limited data exists on the prevalence, types, and clinical factors associated with colonic polyps in pediatric populations.
- Understanding these aspects is crucial for accurate diagnosis and management.
Purpose of the Study:
- To determine the prevalence of colorectal polyps in a large cohort of children undergoing colonoscopy.
- To identify associated demographic and clinical factors.
Main Methods:
- A cross-sectional study analyzed 13,115 colonoscopies in children (0-20 years) from January 2000 to December 2007.
- Data from the Pediatric Endoscopy Database System Clinical Outcomes Research Initiative (PEDS-CORI) was used, comparing polyp cases with non-polyp cases.
- Histopathologic reports from a subset of patients were reviewed.
Main Results:
- Colorectal polyps were identified in 6.1% of procedures (810/13,115) and in 12% of patients with lower gastrointestinal bleeding.
- Children with polyps were younger, more likely to be male, non-white, and presented with lower GI bleeding compared to those without polyps.
- Histological analysis revealed juvenile polyps (solitary or multiple) as the most common type (86%), followed by adenomas (10.9%).
Conclusions:
- Colorectal polyps are a significant finding in pediatric colonoscopies, occurring in 6.1% overall and 12% of those with lower GI bleeding.
- Juvenile polyps and adenomas comprise a substantial proportion (approximately 26%) of pediatric colorectal polyps.
- Further research into clinical determinants and long-term outcomes is warranted.
Background:
The available data regarding the prevalence, types, and clinical determinants of colonic polyps in children is limited.
Aims:
We aimed to estimate the prevalence of colorectal polyps in a large cohort of children.
Methods:
We conducted a cross-sectional study to determine the presence, number, and location of colorectal polyps reported in all children (0-20 years) who underwent colonoscopy at 14 pediatric facilities between January 2000 and December 2007 recorded in Pediatric Endoscopy Database System Clinical Outcomes Research Initiative (PEDS-CORI). We compared procedures with and without polyps with respect to procedure indication, age, sex, and race. We also reviewed a sample of histopathologic reports from one participating center.
Results:
We analyzed 13,115 colonoscopy procedures performed in 11,637 patients. Colorectal polyps were reported in 810 procedures (6.1%; 95% CI: 5.7-6.5%) performed in 705 patients, and in 12% of patients with lower GI bleeding. Children with colorectal polyps were significantly younger (8.9 years vs. 11.9 years; p < 0.0001), male (58.3% vs. 49.0%; p < 0.001), non-white race (27.5% vs. 21.9%; p < 0.001), and had lower GI bleeding (54.4% vs. 26.6%; p < 0.001) as compared to children without polyps. In a sample of 122 patients with polyps from a single center, the histological types were solitary juvenile in 91 (70.5%), multiple juvenile in 20 (15.5%), adenoma in 14 (10.9%) and hyperplastic polyps in four patients (3.1%).
Conclusions:
Colorectal polyps are detected in 6.1% overall and in 12.0% among those with lower gastrointestinal bleeding during pediatric colonoscopy. Approximately 26% are multiple juvenile or adenoma.
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