Vascular response to cyclosporine and verapamil in the rat pancreas

Marked elevation of vascular resistance in the rat pancreas is shown after systemic infusion of cyclosporine. Verapamil administration after cyclosporine reversed this effect and allowed maintenance of baseline vascular resistance and blood flow to the pancreas despite additional infusions of cyclosporine. Cyclosporine toxicity in rat pancreas may be directly related to increased vascular resistance. Verapamil might offer protection from this effect.