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Updated: May 26, 2026
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Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
Published on: January 9, 2019
Lymphoma study group of JCOG
Kunihiro Tsukasaki1, Kensei Tobinai, Tomomitu Hotta
1Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Science, Sakamoto, Nagasaki, Japan. tsukasak@net.nagasaki-u.ac.jp
Japanese Journal of Clinical Oncology
|December 8, 2011
Summary
The Japan Clinical Oncology Group (JCOG) Lymphoma Study Group (LSG) has conducted over 30 trials for lymphoid malignancies. Their research established standard therapies for adult T-cell leukemia-lymphoma and led to new treatments for B-cell lymphomas.
Area of Science:
- Hematology
- Oncology
- Clinical Trials
Background:
- The Japan Clinical Oncology Group (JCOG) Lymphoma Study Group (LSG), established in 1978, comprises 47 institutions.
- LSG research focuses on combined modalities, dose intensification, and novel agents for lymphoid malignancies.
Purpose of the Study:
- To summarize the JCOG-LSG's extensive clinical trial experience in lymphoid malignancies.
- To highlight key findings and therapeutic advancements in non-Hodgkin's lymphoma, adult T-cell leukemia-lymphoma, Hodgkin's lymphoma, and multiple myeloma.
Main Methods:
- Conducted over 30 trials, including 10 randomized trials, for various lymphoid malignancies.
- Performed correlative epidemiological and pathological studies, including those on human T-lymphotropic virus type-I.
- Evaluated regimens incorporating rituximab for B-cell lymphomas and new modalities like molecular-targeting agents.
Main Results:
- Established a subclassification of adult T-cell leukemia-lymphoma (ATL) and standard therapies for ATL and localized nasal NK/T-NHL.
- Trials for Hodgkin's lymphoma (HL) led to the approval of dacarbazine in Japan.
- Recent evaluations of rituximab-containing regimens for B-cell lymphomas show promise.
Conclusions:
- JCOG-LSG trials have significantly improved the understanding and treatment of lymphoid malignancies.
- Ongoing multicenter trials incorporating novel agents are expected to further advance treatment outcomes.
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