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Related Concept Videos

Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Accessory Structures of the Skin: Sweat Glands01:20

Accessory Structures of the Skin: Sweat Glands

Sweat glands or sudoriferous glands are one of the important accessory structures of the skin. They are small, coiled tubular structures located in the dermis, the middle layer of the skin. Sweat glands are responsible for producing and secreting sweat, a watery fluid that helps regulate body temperature and excrete waste products.
Sweat glands are classified as merocrine glands; that is, the secretions are excreted by exocytosis through a duct without affecting the cells of the gland. There...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...

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Related Experiment Video

Updated: May 26, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Giant vascular eccrine spiradenoma.

Min Ho Kim1, Eujin Cho, Jeong Deuk Lee

  • 1Department of Dermatology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Annals of Dermatology
|December 8, 2011
PubMed
Summary
This summary is machine-generated.

Giant vascular eccrine spiradenomas (GVESs), a rare sweat gland tumor variant, are typically large and vascular. This report details an unusual GVES case lacking common bleeding or ulceration signs.

Keywords:
Eccrine spiradenomaGiant vascular eccrine spiradenomaSweat gland neoplasms

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A Patient-Derived Xenograft Model for Venous Malformation
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A Patient-Derived Xenograft Model for Venous Malformation

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Last Updated: May 26, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

A Patient-Derived Xenograft Model for Venous Malformation
06:51

A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Giant vascular eccrine spiradenomas (GVESs) are uncommon neoplasms originating from sweat glands.
  • GVESs are characterized by larger size and increased vascularity compared to typical eccrine spiradenomas.
  • Clinical presentation often includes bleeding or ulceration, leading to misdiagnosis.

Observation:

  • This study presents a rare case of GVES.
  • The reported GVES case did not exhibit typical bleeding or ulceration.
  • This atypical presentation highlights diagnostic challenges.

Findings:

  • The case demonstrates that GVES can present without bleeding or ulceration.
  • This challenges the conventional clinical diagnostic criteria for GVES.
  • Histopathological confirmation remains crucial for accurate diagnosis.

Implications:

  • This case expands the clinical spectrum of GVES.
  • It underscores the importance of considering GVES even in the absence of bleeding or ulceration.
  • Further research may refine diagnostic guidelines for this rare tumor.