Multiple unilateral zosteriform connective tissue nevi on the trunk

Area of Science:

• Dermatology
• Pathology

Background:

• Connective tissue nevus is a benign hamartoma, not a true neoplasm, affecting skin components.
• It typically manifests as a solitary, slow-growing nodule or plaque, often present since childhood.
• Lesions commonly appear on the trunk and extremities.

Observation:

• A 20-month-old girl presented with multiple, unilateral, zosteriform plaques on the left chest and abdomen.
• These lesions developed over 17 months and were asymptomatic.
• This presentation is unique as previously reported cases involved single lesions.

Findings:

• The child exhibited multiple unilateral zosteriform lesions of connective tissue nevus.
• The distribution pattern was unusual, differing from previously documented cases.
• No evidence of tuberous sclerosis complex was found.

Implications:

• This case expands the understanding of connective tissue nevus presentation in pediatric patients.
• It suggests that multiple, zosteriform lesions can occur without associated systemic conditions.
• Further research may explore genetic or developmental factors contributing to varied presentations.