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βhCG and PAPP-A in first trimester: predictive factors for preeclampsia?
Barbara Mikat1, Anna Zeller, André Scherag
1Department of Gynecology and Obstetrics, University of Duisburg-Essen, Essen, Germany. barbara.mikat@uk-essen.de
Objective:
The aim of our study was to investigate a possible correlation between the expression of the placenta-secreted hormones, β-subunit of human chorionic gonadotrophin (βhCG) and pregnancy-associated plasma protein A (PAPP-A), during the first trimester screening and the development of preeclampsia.
Methods:
A total of 155 patients between 11 + 0 and 13 + 6 weeks of gestation were enrolled in this study. PAPP-A and βhCG levels were measured using the KRYPTOR® system.
Results:
The serum levels of βhCG were significantly higher in pregnancies which subsequently developed preeclampsia. The PAPP-A concentration did not differ significantly in pregnancies complicated by preeclampsia than in uncomplicated pregnancies.
Conclusion:
These results might contribute to developing new tests in the prediction of preeclampsia.
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