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Updated: May 26, 2026
Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Published on: August 16, 2018
A mouse monoclonal antibody against the γ2 subunit of GABAA receptors
Suchitra Joshi1, Chengsan Sun, Jaideep Kapur
1Department of Neurology, University of Virginia, Health Sciences Center, Charlottesville, 22908, USA.
Abstract:
A mouse monoclonal antibody directed against the N terminal extracellular epitope of rat γ amino butyric acid (GABA) type-A (GABA(A)R) receptor γ2 subunit was generated. This antibody identified a protein of approximately 42 kDa in Western blot assays using rat and mouse hippocampal proteins. The antibody also detected the expression of γ2 subunit by immunohistochemistry and could immunoprecipitate the γ2 subunit.
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