Associations between BODE index and systemic inflammatory biomarkers in COPD
Eleni Gaki1, Konstantina Kontogianni, Andriana I Papaioannou
12nd Respiratory Medicine Department, University of Athens Medical School, Attikon Hospital, Rimini 1, Athens, Greece.
COPD
|December 14, 2011
Summary
The BODE index and fat-free mass index (FFMI) in COPD patients are linked to leptin levels, suggesting leptin
Area of Science:
- Pulmonary Medicine
- Biochemistry
- Inflammation Research
Background:
- Chronic Obstructive Pulmonary Disease (COPD) is a complex disease with systemic effects.
- Systemic inflammation contributes to COPD's manifestations like muscle weakness and cachexia.
- Fat-free mass index (FFMI) correlates with COPD symptoms and exercise capacity.
Purpose of the Study:
- To investigate the relationship between the multidimensional BODE index and systemic inflammation biomarkers in COPD.
- To evaluate the association between FFMI and systemic inflammation markers.
Main Methods:
- Calculated BODE index and FFMI in 222 stable COPD patients and 132 healthy controls (smokers/ex-smokers).
- Measured serum levels of leptin, adiponectin, C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α).
Main Results:
- In COPD patients, BODE index and FFMI showed significant associations with leptin levels (R² 0.61 and 0.65).
- FFMI also demonstrated a negative association with TNF-α levels (R² 0.38).
- No significant associations were found in healthy controls.
Conclusions:
- BODE index and FFMI are related to circulating leptin levels in COPD patients.
- Leptin may play a role in the systemic aspects of COPD.
- The link between FFMI and TNF-α suggests systemic inflammation's involvement in COPD muscle wasting.
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