Related Experiment Video
Updated: Aug 13, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
[Idiopathic skin calcinosis with transepithelial elimination]
M J Diogenes1, M E Cabral, N S Michalany
1Faculdade de Medicina, Universidade Federal do Ceará.
Idiopathic calcinosis, a rare skin condition, manifested universally and progressed to epidermal perforation. Treatment with aluminum hydroxide was administered, highlighting the phenomenon of transepidermal elimination.
Area of Science:
- Dermatology
- Pathology
Background:
- Idiopathic calcinosis is a rare condition characterized by calcium deposition in the skin.
- Understanding its etiology and progression is crucial for effective management.
Observation:
- A unique case of universal cutaneous calcinosis developed without a discernible cause.
- The condition evolved, leading to epidermal perforation.
Findings:
- The case highlights the rarity of idiopathic calcinosis.
- Transepidermal elimination, a process where substances are expelled through the epidermis, was observed.
- Aluminum hydroxide was used as a treatment modality.
Implications:
- This case contributes to the understanding of rare dermatological conditions.
- Further research into the mechanisms of idiopathic calcinosis and transepidermal elimination is warranted.
- Exploring novel treatment strategies for extensive cutaneous calcification is important.
Related Concept Videos
Role of Skin in Vitamin D Synthesis
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Drug Elimination by Renal Route: Tubular Secretion
Drug Excretion: Miscellaneous Routes
Urinary Tract Calculi I: Introduction
Staphylococcal Skin Infections
Inflammatory Bowel Disease II: Ulcerative Colitis

