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Increased stability of S-nitrosothiol solutions via pH modulations

István Hornyák1, Krisztina Marosi, Levente Kiss

  • 1Semmelweis University, Department of Human Physiology and Clinical Experimental Research, Budapest, Hungary. istvan.hornyak@eok.sote.hu

Free Radical Research
|December 14, 2011
PubMed
Summary

Optimizing pH to mildly basic conditions (8.4-8.8) significantly slows the decomposition of S-nitrosothiols (RSNOs). This stabilization, especially in polymer matrices, preserves nitric oxide-releasing capacity for potential topical vasodilator therapies.

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