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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

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Related Experiment Video

Updated: May 26, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

Targeting NOTCH1 in hematopoietic malignancy.

Giovanni Roti1, Kimberly Stegmaier

  • 1Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02215, USA.

Critical Reviews in Oncogenesis
|December 14, 2011
PubMed
Summary
This summary is machine-generated.

Targeting NOTCH1 mutations in leukemia is promising, but challenges exist due to its role in normal cell development. This review explores therapeutic strategies and their complexities.

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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors

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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

Area of Science:

  • Oncology
  • Molecular Biology
  • Hematology

Background:

  • NOTCH1 activating mutations are prevalent in T-cell acute lymphoblastic leukemia (T-ALL) and chronic lymphocytic leukemia (CLL).
  • NOTCH1 plays a critical role in normal cell-fate specification and differentiation.
  • Its validated role in pathogenesis supports NOTCH1 as a therapeutic target in hematopoietic malignancies.

Purpose of the Study:

  • To review potential therapeutic strategies for targeting NOTCH1 in hematopoietic malignancies.
  • To discuss the challenges associated with these strategies and potential solutions.

Main Methods:

  • Review of existing literature on NOTCH1 targeting in hematopoietic malignancies.
  • Analysis of different therapeutic approaches including enzyme inhibition, antibody therapy, and transcriptional complex interference.

Main Results:

  • NOTCH1 mutations are frequent in T-ALL (>50%) and present in CLL (12%).
  • Therapeutic strategies include inhibiting activating enzymes, using receptor/ligand antibodies, or interfering with the transcriptional complex.
  • Each approach presents unique challenges due to NOTCH1's essential functions.

Conclusions:

  • Targeting NOTCH1 offers a promising therapeutic avenue for hematopoietic malignancies.
  • Overcoming challenges related to NOTCH1's normal functions is crucial for successful therapeutic development.
  • Further research into specific targeting mechanisms and solutions is warranted.