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Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Cardiac Cycle

The cardiac cycle refers to the sequence of events that occur in the heart from the beginning of one heartbeat to the next. It's characterized by alternating periods of contraction (systole) and relaxation (diastole) of the heart muscles.
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Specialized Characteristics of Cardiac Muscles01:27

Specialized Characteristics of Cardiac Muscles

The primary role of cardiac muscles is to propel blood throughout the cardiovascular system. The cardiac muscle cells, or cardiomyocytes, exhibit specialized characteristics that allow them to perform this function.
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Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Imbalances in Cardiac Output

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Related Experiment Video

Updated: May 26, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

Diastolic cardiac function is synonymous with long-axis systolic function: a novel concept in cardiac function.

Akihiro Kurita1, Koichi Kono, Hiroshi Morita

  • 1Department of Hygiene and Public Health, Osaka Medical College, Takatsuki City, Osaka, Japan. sunny.blue59@gmail.com

Echocardiography (Mount Kisco, N.Y.)
|December 14, 2011
PubMed
Summary

Long-axis cardiac function significantly correlates with diastolic cardiac function. The e'/a' ratio is a reliable index for assessing long-axis cardiac function, offering valuable insights into heart mechanics.

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Last Updated: May 26, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
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Area of Science:

  • Cardiology
  • Cardiac Physiology
  • Diagnostic Imaging

Background:

  • Speculation exists regarding the interplay between diastolic cardiac function and long-axis cardiac function.
  • Understanding this relationship is crucial for comprehensive cardiac assessment.

Purpose of the Study:

  • To investigate and provide conclusive evidence on the relationship between diastolic cardiac function and long-axis cardiac function.
  • To evaluate specific echocardiographic and cardiac magnetic resonance imaging parameters.

Main Methods:

  • Echocardiography and cardiac magnetic resonance imaging were performed on 33 subjects.
  • Longitudinal fractional shortening and left ventricular wall length shortening were measured.
  • Correlations between long-axis function and diastolic function parameters were analyzed.

Main Results:

  • A significant correlation was observed between diastolic cardiac function and long-axis systolic function.
  • Spearman correlation coefficients demonstrated strong relationships: E/A (0.76), E/e' (-0.77), e' (0.87), and e'/a' (0.91).
  • The e'/a' ratio showed a particularly strong correlation with longitudinal fractional shortening.

Conclusions:

  • Long-axis cardiac function is well-correlated with diastolic cardiac function.
  • The e'/a' ratio emerges as a promising index for assessing long-axis cardiac function.
  • This finding aids in the non-invasive evaluation of cardiac mechanics.