Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lipids in gap junction assembly and function.

B Malewicz1, V V Kumar, R G Johnson

  • 1Hormel Institute, University of Minnesota, Austin 55912.

Lipids
|August 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Po uptake in microalgae at different seawater pH: An experimental study simulating ocean acidification.

Marine pollution bulletin·2020
Same author

Prenatal and early life exposure to air pollution induced hippocampal vascular leakage and impaired neurogenesis in association with behavioral deficits.

Translational psychiatry·2018
Same author

Osseous response on linear and cyclic RGD-peptides immobilized on titanium surfaces in vitro and in vivo.

Journal of biomedical materials research. Part A·2017
Same author

Mass spectrometric analysis of mono- and dialkyl ethers of diols.

Lipids·2016
Same author

Editorial.

Lipids·2016
Same author

Mass spectrometric analysis of long chain alk-1-enyl ether esters and alkyl ether esters of diols.

Lipids·2016
Same journal

Oral Delivery of Tocotrienols: Addressing Pharmacokinetic Challenges With Formulation-Based Strategies.

Lipids·2026
Same journal

Very Low Cholesterol Non-Cardiovascular Risks: A Critical Appraisal and Framework for Individualized Management.

Lipids·2026
Same journal

Exometabolomics Reveals Metabolic Modulation Induced by Chia Oil Supplementation in Adipose Tissue Explants From Obese Mice.

Lipids·2026
Same journal

Analysis of the Value of Combined Detection of Serum miR-302a-3p and Low Density Lipoprotein Cholesterol in the Diagnosis of Coronary Heart Disease.

Lipids·2026
Same journal

Association Between C-Reactive Protein-Triglyceride Glucose Index, and the Risk of Osteoarthritis and Rheumatoid Arthritis: Results From NHANES 1999-2010.

Lipids·2026
Same journal

Transcriptomic Analysis of Shared Lipid Metabolism in Chronic Hepatitis B and Non-Alcoholic Fatty Liver Disease Using Weighted Gene Expression Network Analysis.

Lipids·2026
See all related articles

Gap junctions (GJ) facilitate cell communication by transferring molecules. This review explores the crucial, yet understudied, role of lipids, particularly cholesterol, in GJ assembly and function.

Area of Science:

  • Cell Biology
  • Membrane Biology

Background:

  • Gap junctions (GJ) are critical for intercellular communication, regulating metabolite transfer and signal transmission.
  • While GJ protein structure is well-studied, the mechanisms controlling their assembly and function remain unclear.
  • The role of lipids in GJ formation and function is largely unknown, despite GJ proteins assembling within the plasma membrane lipid environment.

Purpose of the Study:

  • To provide a comprehensive review of current knowledge on gap junction lipids.
  • To discuss the involvement of lipids in gap junction formation.
  • To emphasize the potential role of membrane cholesterol in gap junction assembly and function.

Main Methods:

  • Literature review of existing research on gap junctions and membrane lipids.

Related Experiment Videos

  • Analysis of studies investigating the impact of lipids on GJ protein assembly and function.
  • Focus on experimental evidence related to cholesterol's influence on GJ dynamics.

    • Main Results:

    • Lipids are integral to the plasma membrane environment where GJ proteins assemble.
    • Specific lipids, including cholesterol, are increasingly recognized for their influence on GJ assembly and stability.
    • Evidence suggests lipids modulate GJ channel activity and overall cellular communication.

    Conclusions:

    • Lipids play a significant, yet underappreciated, role in regulating gap junction assembly and function.
    • Further research into lipid-protein interactions is essential for understanding GJ regulation.
    • Membrane cholesterol is a key factor potentially influencing gap junction dynamics and cellular processes.