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Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
Published on: July 10, 2012
Pneumonia in allogeneic stem cell transplantation recipients: a multicenter prospective study
Manuela Aguilar-Guisado1, Margarita Jiménez-Jambrina, Ildefonso Espigado
1Hospital Virgen del Rocío, Sevilla, Spain. maguilarguisado@yahoo.es
Clinical Transplantation
|December 14, 2011
Summary
Pneumonia is a significant cause of death following allogeneic hematopoietic stem cell transplantation (allo-HSCT). This study details current pneumonia incidence, causes, and outcomes in allo-HSCT patients, highlighting its impact on survival.
Area of Science:
- Infectious Diseases
- Hematology
- Transplantation Medicine
Background:
- Pneumonia frequently causes mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
- Existing data on pneumonia in allo-HSCT recipients is limited and requires updating.
- Prospective, nationwide studies are crucial for understanding current trends.
Purpose of the Study:
- To investigate the current epidemiology of pneumonia in allo-HSCT recipients.
- To identify the primary etiological agents responsible for pneumonia post-allo-HSCT.
- To determine the outcomes and mortality associated with pneumonia in this patient population.
Main Methods:
- A nationwide prospective study conducted from September 2003 to November 2005.
- Inclusion of 112 pneumonia episodes in 427 consecutive allo-HSCT recipients.
- Microbiological analysis to define pneumonia etiology in 72% of cases.
Main Results:
- Pneumonia incidence was 52.2 per 100 allo-HSCT/year.
- Bacterial pneumonia (44.4%) was most common, followed by fungal (29.2%) and viral (19.4%).
- Key pathogens included Escherichia coli, Streptococcus pneumoniae, cytomegalovirus, and Aspergillus spp.
- Pneumonia and chronic graft-versus-host disease (GVHD) significantly increased mortality.
- Survival probability was lower in patients with any pneumonia episode (p < 0.01).
Conclusions:
- Pneumonia remains a frequent and significant cause of mortality after allo-HSCT.
- Early pneumonia, fungal infections, GVHD, and acute respiratory failure are associated with higher mortality.
- This study provides current insights into pneumonia's incidence, etiology, and outcomes in allo-HSCT patients.
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