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Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...

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Related Experiment Video

Updated: May 26, 2026

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
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Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

Inflammation and cancer: a comparative view.

Wallace B Morrison1

  • 1Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN, USA. wbm@purdue.edu

Journal of Veterinary Internal Medicine
|December 14, 2011
PubMed
Summary
This summary is machine-generated.

Inflammation, linked to infections and free radicals, is a major risk factor for cancer. It promotes tumor growth, survival, and spread by damaging DNA and disrupting cell processes.

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Multiplex Immunohistochemical Analysis of the Spatial Immune Cell Landscape of the Tumor Microenvironment
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Published on: August 18, 2023

Related Experiment Videos

Last Updated: May 26, 2026

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
06:24

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

Multiplex Immunohistochemical Analysis of the Spatial Immune Cell Landscape of the Tumor Microenvironment
06:32

Multiplex Immunohistochemical Analysis of the Spatial Immune Cell Landscape of the Tumor Microenvironment

Published on: August 18, 2023

Area of Science:

  • Oncology
  • Immunology
  • Pathology

Background:

  • The link between inflammation and cancer was first proposed over 150 years ago.
  • Chronic inflammation, infections, and free radical overload are significant risk factors for cancer development, accounting for 25% of human cancers globally.
  • Viruses can also contribute to cancer, either directly or indirectly through inflammatory pathways.

Purpose of the Study:

  • To explore the multifaceted role of inflammation in cancer initiation and progression.
  • To highlight how inflammation in the tumor microenvironment supports malignant cell survival and metastasis.

Main Methods:

  • Review of historical and current scientific literature on inflammation and cancer.
  • Analysis of molecular mechanisms linking inflammatory mediators to cancer development.

Main Results:

  • Inflammation promotes cancer by aiding malignant cell proliferation, survival, angiogenesis, and metastasis.
  • Inflammatory mediators like cytokines and free radicals can cause DNA damage and alter protein functions crucial for cancer suppression.
  • Even non-inflammatory viruses can initiate or promote cancer via inflammatory signaling pathways.

Conclusions:

  • Inflammation, regardless of its origin, plays a critical role in promoting cancer.
  • Understanding the inflammatory mechanisms driving cancer is essential for developing effective prevention and treatment strategies.