Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Knowledge and perceptions of medical practitioners on the role of nutrition in systemic sclerosis.

Journal of scleroderma and related disorders·2026
Same author

Methodology and quality assurance practices in performing anti-extractable nuclear antigen (ENA) analysis: an EFLM report on an international survey.

Clinical chemistry and laboratory medicine·2026
Same author

Translation and Validation of the Greek Version of the Revised Fibromyalgia Impact Questionnaire (FIQR).

Mediterranean journal of rheumatology·2026
Same author

Apremilast therapy increases CD39<sup>+</sup>CD4<sup>+</sup> T cells in peripheral blood of patients with psoriatic disease: a retrospective observational pilot study.

Rheumatology international·2026
Same author

Systemic lupus erythematosus is associated with an increased risk for orthorexia nervosa: a cross-sectional study.

Rheumatology international·2026
Same author

Janus kinase inhibitors in giant cell arteritis: unmet needs and new challenges.

Reumatologia·2026

Related Experiment Video

Updated: May 26, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
06:27

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells

Published on: May 6, 2013

Type 1 autoimmune pancreatitis.

Yoh Zen1, Dimitrios P Bogdanos, Shigeyuki Kawa

  • 1Institute of Liver Studies, King's College Hospital and King's College London School of Medicine, Denmark Hill, London SE5 9RS, UK. yoh.zen@kcl.ac.uk

Orphanet Journal of Rare Diseases
|December 14, 2011
PubMed
Summary
This summary is machine-generated.

Autoimmune pancreatitis (AIP) is a treatable condition characterized by elevated serum IgG4 levels. Early diagnosis through serological, imaging, and histological findings is crucial for effective steroid therapy, distinguishing it from pancreatic cancer.

More Related Videos

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
14:39

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

Published on: January 9, 2026

Isolation of Human Islets from Partially Pancreatectomized Patients
11:10

Isolation of Human Islets from Partially Pancreatectomized Patients

Published on: July 30, 2011

Related Experiment Videos

Last Updated: May 26, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
06:27

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells

Published on: May 6, 2013

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
14:39

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

Published on: January 9, 2026

Isolation of Human Islets from Partially Pancreatectomized Patients
11:10

Isolation of Human Islets from Partially Pancreatectomized Patients

Published on: July 30, 2011

Area of Science:

  • Gastroenterology and Immunology
  • Pancreatic Diseases
  • Autoimmune Disorders

Background:

  • Autoimmune pancreatitis (AIP) was previously recognized by histological features, but serum IgG4 elevation in 2001 led to wider acceptance.
  • AIP is now classified into Type 1 and Type 2, with Type 1 predominantly affecting adult males and accounting for 2% of chronic pancreatitis cases.

Purpose of the Study:

  • To provide a comprehensive overview of Type 1 autoimmune pancreatitis (AIP).
  • To highlight diagnostic criteria, differential diagnoses, and treatment of AIP.
  • To discuss the relationship between AIP and IgG4-related disease.

Main Methods:

  • Review of serological findings, including elevated serum IgG4 as a key diagnostic marker.
  • Analysis of characteristic imaging features such as pancreatic duct narrowing and organ enlargement.
  • Examination of histological findings including lymphoplasmacytic infiltration and fibrosis.

Main Results:

  • Type 1 AIP presents with obstructive jaundice and requires differentiation from pancreatic cancer.
  • Diagnostic hallmarks include elevated IgG4, specific imaging patterns, and characteristic histopathology.
  • A significant response to steroid therapy is observed, with rapid serological and radiological improvements.

Conclusions:

  • Type 1 AIP is considered a pancreatic manifestation of systemic IgG4-related disease, affecting multiple organs.
  • Understanding the immune mechanisms involving Th2 responses and regulatory T-cells is ongoing.
  • Recognizing AIP is vital due to its distinct characteristics and responsiveness to steroid treatment.